Genome analysis of 17 extensively drug-resistant strains reveals new potential mutations for resistance

H. Guio; D. Tarazona; M. Galarza; V. Borda; R. Curitomay

doi:10.1128/genomeA.00759-14

Genome analysis of 17 extensively drug-resistant strains reveals new potential mutations for resistance

H. Guio
, D. Tarazona
, M. Galarza
, V. Borda
, R. Curitomay

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

6 Citas (Scopus)

Resumen

We report the whole-genome sequence of an extensively drug-resistant (XDR) tuberculosis (TB) strain of Latin American-Mediterranean (LAM) lineage. This strain is phenotypically resistant to aminoglycosides, but carries no related mutations in rrs, tlyA, and eis. Through genome analysis comparison with 16 XDR strains, we found 218 non-synonymous single nucleotide polymorphisms (SNPs) shared that could confer resistance.

Idioma original	Inglés
Número de artículo	e00759-14
Publicación	Genome Announcements
Volumen	2
N.º	4
DOI	https://doi.org/10.1128/genomeA.00759-14
Estado	Publicada - 2014
Publicado de forma externa	Sí

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abstract = "We report the whole-genome sequence of an extensively drug-resistant (XDR) tuberculosis (TB) strain of Latin American-Mediterranean (LAM) lineage. This strain is phenotypically resistant to aminoglycosides, but carries no related mutations in rrs, tlyA, and eis. Through genome analysis comparison with 16 XDR strains, we found 218 non-synonymous single nucleotide polymorphisms (SNPs) shared that could confer resistance.",

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AU - Borda, V.

AU - Curitomay, R.

PY - 2014

Y1 - 2014

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AB - We report the whole-genome sequence of an extensively drug-resistant (XDR) tuberculosis (TB) strain of Latin American-Mediterranean (LAM) lineage. This strain is phenotypically resistant to aminoglycosides, but carries no related mutations in rrs, tlyA, and eis. Through genome analysis comparison with 16 XDR strains, we found 218 non-synonymous single nucleotide polymorphisms (SNPs) shared that could confer resistance.

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Genome analysis of 17 extensively drug-resistant strains reveals new potential mutations for resistance

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