TY - JOUR
T1 - Effect of pro-inflammatory cytokine stimulation on human breast cancer
T2 - Implications of chemokine receptor expression in cancer metastasis
AU - Valdivia-Silva, Julio E.
AU - Franco-Barraza, Janusz
AU - Silva, Ana Luisa Esparza
AU - Pont, Gisela Du
AU - Soldevila, Gloria
AU - Meza, Isaura
AU - García-Zepeda, Eduardo A.
N1 - Funding Information:
We would like to thank Dr. Guillermo Alfaro (in memoriam) for his valuable support and provide us with cell lines. This work was supported in part by a CONACyT grant to EGZ (58294) and to IM (42724). JVS, JFB (172665), and AES were supported by a Doctoral Fellowship from CONACyT.
PY - 2009/10/8
Y1 - 2009/10/8
N2 - Interactions between tumour cells and microenvironments may affect their growth and metastasis formation. In search for a better understanding of the role of cellular mediators in the progression of cancer, we investigated the effect of pro-inflammatory cytokines IL-1, IL-6, TNF-α and IFN-γ on the regulation of expression of chemokine receptors CXCR4, CXCR2, CX3CR1, CCR9, and CCR5 in the human breast cancer cell line MCF-7. Our results showed that IL-1 increased CXCR4 expression whereas TNF-α increased CX3CR1, CCR9 and CCR5. Interestingly, this regulation was not homogeneous, emphasizing the inherent heterogeneity in cancer that may be responsive to specific inflammatory microenvironments.
AB - Interactions between tumour cells and microenvironments may affect their growth and metastasis formation. In search for a better understanding of the role of cellular mediators in the progression of cancer, we investigated the effect of pro-inflammatory cytokines IL-1, IL-6, TNF-α and IFN-γ on the regulation of expression of chemokine receptors CXCR4, CXCR2, CX3CR1, CCR9, and CCR5 in the human breast cancer cell line MCF-7. Our results showed that IL-1 increased CXCR4 expression whereas TNF-α increased CX3CR1, CCR9 and CCR5. Interestingly, this regulation was not homogeneous, emphasizing the inherent heterogeneity in cancer that may be responsive to specific inflammatory microenvironments.
KW - Chemokine
KW - Chemokine receptor
KW - Cytokine
KW - Inflammation
KW - Invasion
UR - http://www.scopus.com/inward/record.url?scp=69849103351&partnerID=8YFLogxK
U2 - 10.1016/j.canlet.2009.03.040
DO - 10.1016/j.canlet.2009.03.040
M3 - Article
C2 - 19409696
AN - SCOPUS:69849103351
SN - 0304-3835
VL - 283
SP - 176
EP - 185
JO - Cancer Letters
JF - Cancer Letters
IS - 2
ER -