The need to diversify genomic studies: Insights from Andean highlanders and Amazonians

Isabela Alvim; Carolina Silva-Carvalho; Marla Mendes de Aquino; Victor Borda; Cesar Sanchez; Carlos Padilla; Omar Cáceres; Isabela Rezende-Diniz; Julia Saraiva-Duarte; Lucas Faria-Costa; Meddly L. Santolalla; Fernanda Rodrigues-Soares; Camila Zolini; Adrián Llerena; Timothy D. O'Connor; Robert H. Gilman; Heinner Guio; Eduardo Tarazona-Santos

doi:10.1016/j.cell.2024.07.009

The need to diversify genomic studies: Insights from Andean highlanders and Amazonians

Isabela Alvim
, Carolina Silva-Carvalho
, Marla Mendes de Aquino
, Victor Borda
, Cesar Sanchez
, Carlos Padilla
, Omar Cáceres
, Isabela Rezende-Diniz
, Julia Saraiva-Duarte
, Lucas Faria-Costa
, Meddly L. Santolalla
, Fernanda Rodrigues-Soares
, Camila Zolini
, Adrián Llerena
, Timothy D. O'Connor
, Robert H. Gilman
, Heinner Guio
, Eduardo Tarazona-Santos

Research output: Contribution to journal › Comment/debate

11 Scopus citations

Abstract

More globally diverse perspectives are needed in genomic studies and precision medicine practices on non-Europeans. Here, we illustrate this by discussing the distribution of clinically actionable genetic variants involved in drug response in Andean highlanders and Amazonians, considering their environment, history, genetic structure, and historical biases in the perception of biological diversity of Native Americans.

Original language	English
Pages (from-to)	4819-4823
Number of pages	5
Journal	Cell
Volume	187
Issue number	18
DOIs	https://doi.org/10.1016/j.cell.2024.07.009
State	Published - 5 Sep 2024
Externally published	Yes

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10.1016/j.cell.2024.07.009

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Alvim, I., Silva-Carvalho, C., Mendes de Aquino, M., Borda, V., Sanchez, C., Padilla, C., Cáceres, O., Rezende-Diniz, I., Saraiva-Duarte, J., Faria-Costa, L., Santolalla, M. L., Rodrigues-Soares, F., Zolini, C., Llerena, A., O'Connor, T. D., Gilman, R. H., Guio, H., & Tarazona-Santos, E. (2024). The need to diversify genomic studies: Insights from Andean highlanders and Amazonians. Cell, 187(18), 4819-4823. https://doi.org/10.1016/j.cell.2024.07.009

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title = "The need to diversify genomic studies: Insights from Andean highlanders and Amazonians",

abstract = "More globally diverse perspectives are needed in genomic studies and precision medicine practices on non-Europeans. Here, we illustrate this by discussing the distribution of clinically actionable genetic variants involved in drug response in Andean highlanders and Amazonians, considering their environment, history, genetic structure, and historical biases in the perception of biological diversity of Native Americans.",

author = "Isabela Alvim and Carolina Silva-Carvalho and \{Mendes de Aquino\}, Marla and Victor Borda and Cesar Sanchez and Carlos Padilla and Omar C{\'a}ceres and Isabela Rezende-Diniz and Julia Saraiva-Duarte and Lucas Faria-Costa and Santolalla, \{Meddly L.\} and Fernanda Rodrigues-Soares and Camila Zolini and Adri{\'a}n Llerena and O'Connor, \{Timothy D.\} and Gilman, \{Robert H.\} and Heinner Guio and Eduardo Tarazona-Santos",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Inc.",

year = "2024",

month = sep,

day = "5",

doi = "10.1016/j.cell.2024.07.009",

language = "English",

volume = "187",

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journal = "Cell",

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Alvim, I, Silva-Carvalho, C, Mendes de Aquino, M, Borda, V, Sanchez, C, Padilla, C, Cáceres, O, Rezende-Diniz, I, Saraiva-Duarte, J, Faria-Costa, L, Santolalla, ML, Rodrigues-Soares, F, Zolini, C, Llerena, A, O'Connor, TD, Gilman, RH, Guio, H & Tarazona-Santos, E 2024, 'The need to diversify genomic studies: Insights from Andean highlanders and Amazonians', Cell, vol. 187, no. 18, pp. 4819-4823. https://doi.org/10.1016/j.cell.2024.07.009

TY - JOUR

T1 - The need to diversify genomic studies

T2 - Insights from Andean highlanders and Amazonians

AU - Alvim, Isabela

AU - Silva-Carvalho, Carolina

AU - Mendes de Aquino, Marla

AU - Borda, Victor

AU - Sanchez, Cesar

AU - Padilla, Carlos

AU - Cáceres, Omar

AU - Rezende-Diniz, Isabela

AU - Saraiva-Duarte, Julia

AU - Faria-Costa, Lucas

AU - Santolalla, Meddly L.

AU - Rodrigues-Soares, Fernanda

AU - Zolini, Camila

AU - Llerena, Adrián

AU - O'Connor, Timothy D.

AU - Gilman, Robert H.

AU - Guio, Heinner

AU - Tarazona-Santos, Eduardo

PY - 2024/9/5

Y1 - 2024/9/5

N2 - More globally diverse perspectives are needed in genomic studies and precision medicine practices on non-Europeans. Here, we illustrate this by discussing the distribution of clinically actionable genetic variants involved in drug response in Andean highlanders and Amazonians, considering their environment, history, genetic structure, and historical biases in the perception of biological diversity of Native Americans.

AB - More globally diverse perspectives are needed in genomic studies and precision medicine practices on non-Europeans. Here, we illustrate this by discussing the distribution of clinically actionable genetic variants involved in drug response in Andean highlanders and Amazonians, considering their environment, history, genetic structure, and historical biases in the perception of biological diversity of Native Americans.

UR - https://www.scopus.com/pages/publications/85203473755

U2 - 10.1016/j.cell.2024.07.009

DO - 10.1016/j.cell.2024.07.009

M3 - Comment/debate

C2 - 39121858

AN - SCOPUS:85203473755

SN - 0092-8674

VL - 187

SP - 4819

EP - 4823

JO - Cell

JF - Cell

IS - 18

ER -

The need to diversify genomic studies: Insights from Andean highlanders and Amazonians

Abstract

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