Genome analysis of 17 extensively drug-resistant strains reveals new potential mutations for resistance

H. Guio; D. Tarazona; M. Galarza; V. Borda; R. Curitomay

doi:10.1128/genomeA.00759-14

Genome analysis of 17 extensively drug-resistant strains reveals new potential mutations for resistance

H. Guio
, D. Tarazona
, M. Galarza
, V. Borda
, R. Curitomay

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

We report the whole-genome sequence of an extensively drug-resistant (XDR) tuberculosis (TB) strain of Latin American-Mediterranean (LAM) lineage. This strain is phenotypically resistant to aminoglycosides, but carries no related mutations in rrs, tlyA, and eis. Through genome analysis comparison with 16 XDR strains, we found 218 non-synonymous single nucleotide polymorphisms (SNPs) shared that could confer resistance.

Original language	English
Article number	e00759-14
Journal	Genome Announcements
Volume	2
Issue number	4
DOIs	https://doi.org/10.1128/genomeA.00759-14
State	Published - 2014
Externally published	Yes

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title = "Genome analysis of 17 extensively drug-resistant strains reveals new potential mutations for resistance",

abstract = "We report the whole-genome sequence of an extensively drug-resistant (XDR) tuberculosis (TB) strain of Latin American-Mediterranean (LAM) lineage. This strain is phenotypically resistant to aminoglycosides, but carries no related mutations in rrs, tlyA, and eis. Through genome analysis comparison with 16 XDR strains, we found 218 non-synonymous single nucleotide polymorphisms (SNPs) shared that could confer resistance.",

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AU - Guio, H.

AU - Tarazona, D.

AU - Galarza, M.

AU - Borda, V.

AU - Curitomay, R.

PY - 2014

Y1 - 2014

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AB - We report the whole-genome sequence of an extensively drug-resistant (XDR) tuberculosis (TB) strain of Latin American-Mediterranean (LAM) lineage. This strain is phenotypically resistant to aminoglycosides, but carries no related mutations in rrs, tlyA, and eis. Through genome analysis comparison with 16 XDR strains, we found 218 non-synonymous single nucleotide polymorphisms (SNPs) shared that could confer resistance.

UR - https://www.scopus.com/pages/publications/85003727748

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DO - 10.1128/genomeA.00759-14

M3 - Article

AN - SCOPUS:85003727748

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VL - 2

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Genome analysis of 17 extensively drug-resistant strains reveals new potential mutations for resistance

Abstract

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