Evidence of clonal expansion in the genome of a multidrug-resistant Mycobacterium tuberculosis clinical isolate from Peru

M. Galarza; D. Tarazona; V. Borda; J. C. Agapito; H. Guio

doi:10.1128/genomeA.e00089-14

Evidence of clonal expansion in the genome of a multidrug-resistant Mycobacterium tuberculosis clinical isolate from Peru

M. Galarza
, D. Tarazona
, V. Borda
, J. C. Agapito
, H. Guio

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We report the genome sequence of Mycobacterium tuberculosis INS-MDR from Peru, a multidrug-resistant tuberculosis (MDRTB) and Latin American-Mediterranean (LAM) lineage strain. Our analysis showed mutations related to drug resistance in the rpoB (D516V), katG (S315T), kasA (G269S), and pncA (Q10R) genes. Our evidence suggests that INS-MDR may be a clonal expansion related to the African strain KZN 1435.

Original language	English
Article number	e00089-14
Journal	Genome Announcements
Volume	2
Issue number	1
DOIs	https://doi.org/10.1128/genomeA.e00089-14
State	Published - 2014
Externally published	Yes

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abstract = "We report the genome sequence of Mycobacterium tuberculosis INS-MDR from Peru, a multidrug-resistant tuberculosis (MDRTB) and Latin American-Mediterranean (LAM) lineage strain. Our analysis showed mutations related to drug resistance in the rpoB (D516V), katG (S315T), kasA (G269S), and pncA (Q10R) genes. Our evidence suggests that INS-MDR may be a clonal expansion related to the African strain KZN 1435.",

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AU - Agapito, J. C.

AU - Guio, H.

PY - 2014

Y1 - 2014

N2 - We report the genome sequence of Mycobacterium tuberculosis INS-MDR from Peru, a multidrug-resistant tuberculosis (MDRTB) and Latin American-Mediterranean (LAM) lineage strain. Our analysis showed mutations related to drug resistance in the rpoB (D516V), katG (S315T), kasA (G269S), and pncA (Q10R) genes. Our evidence suggests that INS-MDR may be a clonal expansion related to the African strain KZN 1435.

AB - We report the genome sequence of Mycobacterium tuberculosis INS-MDR from Peru, a multidrug-resistant tuberculosis (MDRTB) and Latin American-Mediterranean (LAM) lineage strain. Our analysis showed mutations related to drug resistance in the rpoB (D516V), katG (S315T), kasA (G269S), and pncA (Q10R) genes. Our evidence suggests that INS-MDR may be a clonal expansion related to the African strain KZN 1435.

UR - https://www.scopus.com/pages/publications/84998706922

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DO - 10.1128/genomeA.e00089-14

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Evidence of clonal expansion in the genome of a multidrug-resistant Mycobacterium tuberculosis clinical isolate from Peru

Abstract

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