Effect of pro-inflammatory cytokine stimulation on human breast cancer: Implications of chemokine receptor expression in cancer metastasis

Julio E. Valdivia-Silva; Janusz Franco-Barraza; Ana Luisa Esparza Silva; Gisela Du Pont; Gloria Soldevila; Isaura Meza; Eduardo A. García-Zepeda

doi:10.1016/j.canlet.2009.03.040

Effect of pro-inflammatory cytokine stimulation on human breast cancer: Implications of chemokine receptor expression in cancer metastasis

Julio E. Valdivia-Silva
, Janusz Franco-Barraza
, Ana Luisa Esparza Silva
, Gisela Du Pont
, Gloria Soldevila
, Isaura Meza
, Eduardo A. García-Zepeda

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Interactions between tumour cells and microenvironments may affect their growth and metastasis formation. In search for a better understanding of the role of cellular mediators in the progression of cancer, we investigated the effect of pro-inflammatory cytokines IL-1, IL-6, TNF-α and IFN-γ on the regulation of expression of chemokine receptors CXCR4, CXCR2, CX3CR1, CCR9, and CCR5 in the human breast cancer cell line MCF-7. Our results showed that IL-1 increased CXCR4 expression whereas TNF-α increased CX3CR1, CCR9 and CCR5. Interestingly, this regulation was not homogeneous, emphasizing the inherent heterogeneity in cancer that may be responsive to specific inflammatory microenvironments.

Original language	English
Pages (from-to)	176-185
Number of pages	10
Journal	Cancer Letters
Volume	283
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2009.03.040
State	Published - 8 Oct 2009
Externally published	Yes

Keywords

Chemokine
Chemokine receptor
Cytokine
Inflammation
Invasion

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10.1016/j.canlet.2009.03.040

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@article{7ef205d0638f45d1b2bc5199617042cf,

title = "Effect of pro-inflammatory cytokine stimulation on human breast cancer: Implications of chemokine receptor expression in cancer metastasis",

abstract = "Interactions between tumour cells and microenvironments may affect their growth and metastasis formation. In search for a better understanding of the role of cellular mediators in the progression of cancer, we investigated the effect of pro-inflammatory cytokines IL-1, IL-6, TNF-α and IFN-γ on the regulation of expression of chemokine receptors CXCR4, CXCR2, CX3CR1, CCR9, and CCR5 in the human breast cancer cell line MCF-7. Our results showed that IL-1 increased CXCR4 expression whereas TNF-α increased CX3CR1, CCR9 and CCR5. Interestingly, this regulation was not homogeneous, emphasizing the inherent heterogeneity in cancer that may be responsive to specific inflammatory microenvironments.",

keywords = "Chemokine, Chemokine receptor, Cytokine, Inflammation, Invasion",

author = "Valdivia-Silva, \{Julio E.\} and Janusz Franco-Barraza and Silva, \{Ana Luisa Esparza\} and Pont, \{Gisela Du\} and Gloria Soldevila and Isaura Meza and Garc{\'i}a-Zepeda, \{Eduardo A.\}",

note = "Funding Information: We would like to thank Dr. Guillermo Alfaro (in memoriam) for his valuable support and provide us with cell lines. This work was supported in part by a CONACyT grant to EGZ (58294) and to IM (42724). JVS, JFB (172665), and AES were supported by a Doctoral Fellowship from CONACyT. ",

year = "2009",

month = oct,

day = "8",

doi = "10.1016/j.canlet.2009.03.040",

language = "English",

volume = "283",

pages = "176--185",

journal = "Cancer Letters",

issn = "0304-3835",

number = "2",

}

TY - JOUR

T1 - Effect of pro-inflammatory cytokine stimulation on human breast cancer

T2 - Implications of chemokine receptor expression in cancer metastasis

AU - Valdivia-Silva, Julio E.

AU - Franco-Barraza, Janusz

AU - Silva, Ana Luisa Esparza

AU - Pont, Gisela Du

AU - Soldevila, Gloria

AU - Meza, Isaura

AU - García-Zepeda, Eduardo A.

N1 - Funding Information: We would like to thank Dr. Guillermo Alfaro (in memoriam) for his valuable support and provide us with cell lines. This work was supported in part by a CONACyT grant to EGZ (58294) and to IM (42724). JVS, JFB (172665), and AES were supported by a Doctoral Fellowship from CONACyT.

PY - 2009/10/8

Y1 - 2009/10/8

N2 - Interactions between tumour cells and microenvironments may affect their growth and metastasis formation. In search for a better understanding of the role of cellular mediators in the progression of cancer, we investigated the effect of pro-inflammatory cytokines IL-1, IL-6, TNF-α and IFN-γ on the regulation of expression of chemokine receptors CXCR4, CXCR2, CX3CR1, CCR9, and CCR5 in the human breast cancer cell line MCF-7. Our results showed that IL-1 increased CXCR4 expression whereas TNF-α increased CX3CR1, CCR9 and CCR5. Interestingly, this regulation was not homogeneous, emphasizing the inherent heterogeneity in cancer that may be responsive to specific inflammatory microenvironments.

AB - Interactions between tumour cells and microenvironments may affect their growth and metastasis formation. In search for a better understanding of the role of cellular mediators in the progression of cancer, we investigated the effect of pro-inflammatory cytokines IL-1, IL-6, TNF-α and IFN-γ on the regulation of expression of chemokine receptors CXCR4, CXCR2, CX3CR1, CCR9, and CCR5 in the human breast cancer cell line MCF-7. Our results showed that IL-1 increased CXCR4 expression whereas TNF-α increased CX3CR1, CCR9 and CCR5. Interestingly, this regulation was not homogeneous, emphasizing the inherent heterogeneity in cancer that may be responsive to specific inflammatory microenvironments.

KW - Chemokine

KW - Chemokine receptor

KW - Cytokine

KW - Inflammation

KW - Invasion

UR - https://www.scopus.com/pages/publications/69849103351

U2 - 10.1016/j.canlet.2009.03.040

DO - 10.1016/j.canlet.2009.03.040

M3 - Article

C2 - 19409696

AN - SCOPUS:69849103351

SN - 0304-3835

VL - 283

SP - 176

EP - 185

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Effect of pro-inflammatory cytokine stimulation on human breast cancer: Implications of chemokine receptor expression in cancer metastasis

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Keywords

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