TY - JOUR
T1 - Computational and experimental analysis of a Glaucoma flat drainage device
AU - Panduro, R. M.R.
AU - Monterrey, Christian
AU - Mantari, J. L.
AU - Canahuire, Ruth
AU - Alvarez, Helard
AU - Miranda, Mario
AU - Elsheikh, Ahmed
N1 - Publisher Copyright:
© 2021
PY - 2021/3/30
Y1 - 2021/3/30
N2 - This paper presents a computational and experimental analysis of a glaucoma flat drainage device (FDD). The FDD consists of a metallic microplate placed into the eye sclerocorneal limbus, which creates a virtual path between the anterior chamber and its exterior, allowing the intraocular pressure (IOP) to be kept in a normal range. It also uses the surrounding tissue as a flow regulator in order to provide close values of IOP for a wide range of aqueous humor (AH) flow rates. The Neo Hookean hyperelastic model is used for the solid part, while the Reynolds thin film fluid model is used for the fluid part. On the other hand, a gravitational-driven flow test is implemented in order to validate the simulation process. An in vitro experiment evaluated the flow characteristics of the device implanted in fourteen extirpated pig eyes, giving as a result the best-fit for the Young modulus of the tissue surrounding the device. Finally, according to the resulting computational model, for a range of 1.4–3.1 μL/min, the device presents a pressure variation range of 6–7.5 mmHg.
AB - This paper presents a computational and experimental analysis of a glaucoma flat drainage device (FDD). The FDD consists of a metallic microplate placed into the eye sclerocorneal limbus, which creates a virtual path between the anterior chamber and its exterior, allowing the intraocular pressure (IOP) to be kept in a normal range. It also uses the surrounding tissue as a flow regulator in order to provide close values of IOP for a wide range of aqueous humor (AH) flow rates. The Neo Hookean hyperelastic model is used for the solid part, while the Reynolds thin film fluid model is used for the fluid part. On the other hand, a gravitational-driven flow test is implemented in order to validate the simulation process. An in vitro experiment evaluated the flow characteristics of the device implanted in fourteen extirpated pig eyes, giving as a result the best-fit for the Young modulus of the tissue surrounding the device. Finally, according to the resulting computational model, for a range of 1.4–3.1 μL/min, the device presents a pressure variation range of 6–7.5 mmHg.
KW - Finite element method
KW - Fluid-structure interaction
KW - Glaucoma
KW - Glaucoma drainage device (GDD)
KW - Thin-film fluid
UR - http://www.scopus.com/inward/record.url?scp=85100375095&partnerID=8YFLogxK
U2 - 10.1016/j.jbiomech.2021.110234
DO - 10.1016/j.jbiomech.2021.110234
M3 - Article
C2 - 33556888
AN - SCOPUS:85100375095
SN - 0021-9290
VL - 118
JO - Journal of Biomechanics
JF - Journal of Biomechanics
M1 - 110234
ER -