Challenges and recommendations in establishing national human diversity genomic projects

Taras K. Oleksyk; Walter W. Wolfsberger; Karishma Chhugani; Yu Ning Huang; Valerii Pokrytiuk; Khrystyna Shchubelka; Alex Zelikovsky; Bogdan Pasaniuc; Viorel Jinga; Octavian Bucur; Scott C. Edmunds; Heinner Guio; Zane Lombard; Brenna M. Henn; Andrei Lobiuc; Alexei Levitchi; Dumitru Ciorba; Viorel Bostan; Viorel Munteanu; Victor Gordeev; Christian P. Schaaf; Boon Peng Hoh; Andrés Moreno Estrada; Mihai Covasa; Mihai Dimian; Ulykbek Kairov; Victoria M. Pak; Shih Wee Seow; Charleston W.K. Chiang; Emmanuel Nepolo; Matteo Pellegrini; Yosr Hamdi; Malak S. Abedalthagafi; Nicola Jane Mulder; Jazlyn Mooney; Javier E. Sanchez-Galan; Sandro José de Souza; Henriette Raventós; Marina Muzzio; Gabriela Chavarria-Soley; Serghei Mangul

doi:10.1038/s41592-026-03131-9

Challenges and recommendations in establishing national human diversity genomic projects

Taras K. Oleksyk
, Walter W. Wolfsberger
, Karishma Chhugani
, Yu Ning Huang
, Valerii Pokrytiuk
, Khrystyna Shchubelka
, Alex Zelikovsky
, Bogdan Pasaniuc
, Viorel Jinga
, Octavian Bucur
, Scott C. Edmunds
, Heinner Guio
, Zane Lombard
, Brenna M. Henn
, Andrei Lobiuc
, Alexei Levitchi
, Dumitru Ciorba
, Viorel Bostan
, Viorel Munteanu
, Victor Gordeev

Christian P. Schaaf, Boon Peng Hoh, Andrés Moreno Estrada, Mihai Covasa, Mihai Dimian, Ulykbek Kairov, Victoria M. Pak, Shih Wee Seow, Charleston W.K. Chiang, Emmanuel Nepolo, Matteo Pellegrini, Yosr Hamdi, Malak S. Abedalthagafi, Nicola Jane Mulder, Jazlyn Mooney, Javier E. Sanchez-Galan, Sandro José de Souza, Henriette Raventós, Marina Muzzio, Gabriela Chavarria-Soley, Serghei Mangul

Department of Bioengineering and Chemical Engineering

Research output: Contribution to journal › Comment/debate

2 Scopus citations

Abstract

To ensure that the benefits of biomedical research are shared globally, we must overcome the barriers preventing the establishment of national genomic projects in underrepresented regions by navigating the ethical, legal and financial complexities of launching these initiatives. We identify seven major challenges — ranging from policy awareness to data privacy regulations — and conclude that successful implementation requires strategic local capacity building and a commitment to open data standards that ensure genomic discoveries are accessible to all.

Original language	English
Pages (from-to)	1261-1266
Number of pages	6
Journal	Nature Methods
Volume	23
Issue number	7
DOIs	https://doi.org/10.1038/s41592-026-03131-9
State	Published - Jul 2026

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Oleksyk, T. K., Wolfsberger, W. W., Chhugani, K., Huang, Y. N., Pokrytiuk, V., Shchubelka, K., Zelikovsky, A., Pasaniuc, B., Jinga, V., Bucur, O., Edmunds, S. C., Guio, H., Lombard, Z., Henn, B. M., Lobiuc, A., Levitchi, A., Ciorba, D., Bostan, V., Munteanu, V., ... Mangul, S. (2026). Challenges and recommendations in establishing national human diversity genomic projects. Nature Methods, 23(7), 1261-1266. https://doi.org/10.1038/s41592-026-03131-9

@article{d6f174805e11482b84d6b3a5e3468000,

title = "Challenges and recommendations in establishing national human diversity genomic projects",

abstract = "To ensure that the benefits of biomedical research are shared globally, we must overcome the barriers preventing the establishment of national genomic projects in underrepresented regions by navigating the ethical, legal and financial complexities of launching these initiatives. We identify seven major challenges {\textemdash} ranging from policy awareness to data privacy regulations {\textemdash} and conclude that successful implementation requires strategic local capacity building and a commitment to open data standards that ensure genomic discoveries are accessible to all.",

author = "Oleksyk, \{Taras K.\} and Wolfsberger, \{Walter W.\} and Karishma Chhugani and Huang, \{Yu Ning\} and Valerii Pokrytiuk and Khrystyna Shchubelka and Alex Zelikovsky and Bogdan Pasaniuc and Viorel Jinga and Octavian Bucur and Edmunds, \{Scott C.\} and Heinner Guio and Zane Lombard and Henn, \{Brenna M.\} and Andrei Lobiuc and Alexei Levitchi and Dumitru Ciorba and Viorel Bostan and Viorel Munteanu and Victor Gordeev and Schaaf, \{Christian P.\} and Hoh, \{Boon Peng\} and \{Moreno Estrada\}, Andr{\'e}s and Mihai Covasa and Mihai Dimian and Ulykbek Kairov and Pak, \{Victoria M.\} and Seow, \{Shih Wee\} and Chiang, \{Charleston W.K.\} and Emmanuel Nepolo and Matteo Pellegrini and Yosr Hamdi and Abedalthagafi, \{Malak S.\} and Mulder, \{Nicola Jane\} and Jazlyn Mooney and Sanchez-Galan, \{Javier E.\} and \{de Souza\}, \{Sandro Jos{\'e}\} and Henriette Ravent{\'o}s and Marina Muzzio and Gabriela Chavarria-Soley and Serghei Mangul",

note = "Publisher Copyright: {\textcopyright} Springer Nature America, Inc. 2026.",

year = "2026",

month = jul,

doi = "10.1038/s41592-026-03131-9",

language = "English",

volume = "23",

pages = "1261--1266",

journal = "Nature Methods",

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Oleksyk, TK, Wolfsberger, WW, Chhugani, K, Huang, YN, Pokrytiuk, V, Shchubelka, K, Zelikovsky, A, Pasaniuc, B, Jinga, V, Bucur, O, Edmunds, SC, Guio, H, Lombard, Z, Henn, BM, Lobiuc, A, Levitchi, A, Ciorba, D, Bostan, V, Munteanu, V, Gordeev, V, Schaaf, CP, Hoh, BP, Moreno Estrada, A, Covasa, M, Dimian, M, Kairov, U, Pak, VM, Seow, SW, Chiang, CWK, Nepolo, E, Pellegrini, M, Hamdi, Y, Abedalthagafi, MS, Mulder, NJ, Mooney, J, Sanchez-Galan, JE, de Souza, SJ, Raventós, H, Muzzio, M, Chavarria-Soley, G & Mangul, S 2026, 'Challenges and recommendations in establishing national human diversity genomic projects', Nature Methods, vol. 23, no. 7, pp. 1261-1266. https://doi.org/10.1038/s41592-026-03131-9

TY - JOUR

T1 - Challenges and recommendations in establishing national human diversity genomic projects

AU - Oleksyk, Taras K.

AU - Wolfsberger, Walter W.

AU - Chhugani, Karishma

AU - Huang, Yu Ning

AU - Pokrytiuk, Valerii

AU - Shchubelka, Khrystyna

AU - Zelikovsky, Alex

AU - Pasaniuc, Bogdan

AU - Jinga, Viorel

AU - Bucur, Octavian

AU - Edmunds, Scott C.

AU - Guio, Heinner

AU - Lombard, Zane

AU - Henn, Brenna M.

AU - Lobiuc, Andrei

AU - Levitchi, Alexei

AU - Ciorba, Dumitru

AU - Bostan, Viorel

AU - Munteanu, Viorel

AU - Gordeev, Victor

AU - Schaaf, Christian P.

AU - Hoh, Boon Peng

AU - Moreno Estrada, Andrés

AU - Covasa, Mihai

AU - Dimian, Mihai

AU - Kairov, Ulykbek

AU - Pak, Victoria M.

AU - Seow, Shih Wee

AU - Chiang, Charleston W.K.

AU - Nepolo, Emmanuel

AU - Pellegrini, Matteo

AU - Hamdi, Yosr

AU - Abedalthagafi, Malak S.

AU - Mulder, Nicola Jane

AU - Mooney, Jazlyn

AU - Sanchez-Galan, Javier E.

AU - de Souza, Sandro José

AU - Raventós, Henriette

AU - Muzzio, Marina

AU - Chavarria-Soley, Gabriela

AU - Mangul, Serghei

PY - 2026/7

Y1 - 2026/7

N2 - To ensure that the benefits of biomedical research are shared globally, we must overcome the barriers preventing the establishment of national genomic projects in underrepresented regions by navigating the ethical, legal and financial complexities of launching these initiatives. We identify seven major challenges — ranging from policy awareness to data privacy regulations — and conclude that successful implementation requires strategic local capacity building and a commitment to open data standards that ensure genomic discoveries are accessible to all.

AB - To ensure that the benefits of biomedical research are shared globally, we must overcome the barriers preventing the establishment of national genomic projects in underrepresented regions by navigating the ethical, legal and financial complexities of launching these initiatives. We identify seven major challenges — ranging from policy awareness to data privacy regulations — and conclude that successful implementation requires strategic local capacity building and a commitment to open data standards that ensure genomic discoveries are accessible to all.

UR - https://www.scopus.com/pages/publications/105042618086

U2 - 10.1038/s41592-026-03131-9

DO - 10.1038/s41592-026-03131-9

M3 - Comment/debate

AN - SCOPUS:105042618086

SN - 1548-7091

VL - 23

SP - 1261

EP - 1266

JO - Nature Methods

JF - Nature Methods

IS - 7

ER -

Challenges and recommendations in establishing national human diversity genomic projects

Abstract

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